Anxiety, anxiety, irritability, resentment, tearfulness and, finally, insomnia ... Each of us at least once in our life has come across such a state of mind and body. The reasons for it can be varied. This is PMS ( premenstrual syndrome), and menopause, and stress, and overwork, and ... pregnancy! What to do if everything seems to be fine: the pregnancy is proceeding normally, the husband is surrounded by love, the family is surrounded by constant care, and in the soul “cats scratch”, pulls to cry, and besides, the dream is running?

In such an emotionally unstable state, quite a few doctors strongly recommend taking Persen during pregnancy.

Persen during pregnancy: indications

Mood swings from euphoria to obsessive anxious thoughts are quite normal for the expectant mother. First, this is due to her unusual state, which motivates her increased sensitivity and alertness: is everything all right? Secondly, hormonal changes in the body "indulge" such emotional instability. In a compartment, this creates fertile ground for anxiety, resentment, worry, with or without, and, as a result, for sleep disorders.

Of course, it is impossible to stay in such a frustrated state of a pregnant woman for a long time, as this can negatively affect the condition and development of the baby. Tranquilizers and other chemical sedatives for the expectant mother are strictly prohibited! We can only take natural sedatives: motherwort, valerian, lemon balm or mint. As all these medicinal plants are part of Persen.

Taking one Persen tablet at night will relieve tension, relieve anxiety and ensure deep healthy sleep. Why at night? The fact is that valerian and lemon balm slightly reduce the reaction and have a sedative effect. In case you plan to be at home all day, or, at the most, go out for a walk accompanied by your spouse or your relatives, you can take persen during the day. But no more than 2-3 dragees.

Remember, even the safest medicine at first sight should not be taken during pregnancy without consulting a doctor. Therefore, it is best to consult your family doctor, tell us about your condition and experiences. He will help you find the exact dosage of Persen.

Persen during pregnancy: prevention, side effects, contraindications

There are practically no contraindications for taking Persen. An exception is individual intolerance to any of its components. But if you are prone to periodic lowering of blood pressure, then Persen during pregnancy should be taken with extreme caution, and it is better to replace it with another drug altogether.

Persen is able to enhance the effect of certain drugs that lower blood pressure and relieve pain. Therefore, if you accept such, you need to be especially careful. As for side effects, they can appear in case of drug overdose. This can manifest itself in dizziness, tremors of the limbs, drowsiness, and stomach cramps. In this condition, you must immediately call a doctor.

Pregnant advice

Of course, sometimes we fail to pull ourselves together, and then we need medicinal " ambulance". But it's better not to bring yourself to such a state. A pregnant woman should remember that a state of peace and inner harmony is one of the cornerstones of her baby's health. Therefore, do not drive yourself to panic states, listening to the stories of "good" friends about "terrible birth pangs" and various congenital deformities. Do not watch disaster films, thrillers or horror films on TV or on the Internet. Read classic literature, study women's magazines, enjoy pleasant relaxing music and walk more in the fresh air. Then you will not need any sedatives.

Editorial staff website wishes you good luck and easy pregnancy, full of pleasant impressions!

Currently all more attention paid to the mental state of a pregnant woman. The reason for such close attention is based on proven facts that indicate that neuropsychic stress directly affects not only the mother's body, but her future, unborn baby.

Pregnancy almost always affects the emotional state of a woman in one way or another, this phenomenon is especially pronounced in the first trimester. There are such moments as frequent mood changes, sleep disturbances, tearfulness, impressionability, resentment, irritability, slight excitability, and in some cases even aggression may appear. All this develops due to the rapidly changing hormonal background.

The manifested moments cannot but affect the physical state, and it happens that it is negative. For example, the course of early toxicosis, which many women are exposed to, can be significantly worsened. If emotional outbursts are strong and often repetitive, there is a chance of premature birth. It is not as easy to get out of this state without outside help as it might seem.

It is for this reason that gynecologists watch closely enough to ensure that women are normal. The expectant mother is recommended to get as much positive emotions as possible, to be in the fresh air a lot, especially before going to bed. But if these recommendations do not have the proper effect, doctors have to resort to the help of medication.

As a rule, any medications are tested for the degree of their effect on the fetus, as well as for the likely risk. For this reason, most often only those drugs are prescribed that are plant-based. One of these drugs is the sedative "Persen".

"Persen" during pregnancy is prescribed carefully only if there is a real threat to the health of the mother or child. Also, caution is observed for the reason that the medicine has not been investigated for the degree of its effect on the female body during pregnancy. The preparation is based only on herbal ingredients, the main ones being the extract of valerian, mint and lemon balm. Only because of the plant base in a given situation, "Persen" during pregnancy can be prescribed by a doctor. Particular care is required, but the longer the period, the less restrictions on drugs.

It is produced, as a rule, in the form of capsules or tablets. Removal of mental stress, normalization of the work of the heart muscles, relaxation of the muscles - all this is able to do "Persen". Contraindications to taking the drug can only be those that relate to the individual intolerance of the components in the drug. For this reason, before you start taking even this, it would seem safe remedy as "Persen" during pregnancy, you must consult your doctor. If it turns out that an individual intolerance to the components is present, another drug will be prescribed. Another contraindication may be low blood pressure, it is also not recommended to take medication if you have to drive, as the reaction rates decrease.

In conclusion, we can say that after compulsory consultation with a doctor, "Persen" during pregnancy may or may not be prescribed. If it turns out that the drug cannot be taken due to low blood pressure or individual intolerance, then brewed vitamins can help.

The main thing that a woman who is going to become a mother must remember is that she should only experience this directly affects the development and health of the future baby.

The period of carrying a baby in the womb does not always do without exciting moments for the expectant mother, because during this period any responsible woman will worry about the results of important screenings, the successful course of pregnancy, and the intrauterine state of the fetus. Many pregnant women worry about the fear of the upcoming birth. Almost all experts agree that unnecessary stress of the expectant mother can adversely affect the condition of the fetus in the womb, primarily due to hypoxia, which occurs when there is insufficient supply of oxygen and nutrients to the fetus. If emotional stress cannot be avoided, a pregnant woman needs outdoor walks, rest, positive thoughts and emotions. In the event that these measures do not give the necessary sedative effect, the obstetrician-gynecologist who supervises the pregnancy may recommend the use of herbal sedatives. When choosing alternative drugs, experts prefer Persen. The use of sedatives and often prescribed drugs based on phenobarbital is strictly prohibited during pregnancy.

Can Persen during pregnancy?

This drug has a strictly plant origin, as it contains extracts of sedative herbs such as valerian, motherwort, lemon balm and peppermint. Persen does not contain phenobarbital, which has a teratogenic effect and negatively affects the formation of the central nervous system of the fetus. This drug is approved during pregnancy and is used in complex therapy and prevention of threatened miscarriage. Doctors often prescribe Persen to eliminate stress, improve sleep, and normalize the nervous system of a pregnant woman. The use of the drug in doses not exceeding therapeutic doses does not have an embryotoxic and teratogenic effect on the developing fetus.

Indications for use

Obstetricians-gynecologists during pregnancy try not to resort to the appointment of sedatives, even those allowed during the period of gestation. Taking the drug is allowed in the first trimester, but it is important for a pregnant woman to avoid taking any medications at the time of laying the vital organs of the fetus. In the case when it is impossible to do without sedatives, the harm from the stress of the mother itself to the fetus will be much greater than the likelihood of harm from the taken herbal sedative pill. The main indications for Persen's appointment are neuratenic states, insomnia, anxiety, tearfulness and irritability, uterine hypertonicity (as a mild antispasmodic). After the 12th week of pregnancy, the drug can be used after consulting a doctor.

How to take Persen

During pregnancy, the regimen for taking the drug is selected by a specialist individually and ranges from 1 to 2 tablets per dose, three times a day for 14-21 days. The tablets must be taken orally with plenty of liquid. It is not recommended to prescribe sedatives even of herbal origin independently, without consulting a gynecologist.

Contraindications and side effects

In general, this drug is well tolerated by the body of a pregnant woman, but in rare cases, side effects such as dizziness, bradycardia, stomach discomfort, lowering blood pressure, short-term darkening in the eyes, and drowsiness are not excluded.

The main contraindication to the use of Persen is the presence of hypersensitivity to the constituent components of the drug, a history of low blood pressure.

All expectant mothers during pregnancy are advised to avoid stressful situations and worries, but if a qualified specialist prescribes Persen's reception, you should not be afraid of using it during this important period of life for every woman.

As mentioned above, mood swings during the period of bearing a child is a normal condition for most women. Since the hormonal background is rebelling, the lady's emotionality is off scale.

That's just in good mood women do not arrive so often, usually they are tormented by increased anxiety, tearfulness, resentment, as a result of which there are problems with sleep and depression.

Such negative emotions and general depression of the expectant mother can affect the development of the fetus. At the same time, a woman should understand that taking any chemical drugs, as well as tranquilizers, in such a difficult period of life is unacceptable.

Expectant mothers during pregnancy are allowed to take only natural sedatives: valerian, motherwort, mint, etc.

Recently, many doctors have prescribed Persen Forte as a sedative during pregnancy, as it is completely natural.

But it is worth noting that, nevertheless, this remedy does not need to be taken in the first trimester of pregnancy, since it is during this period that all vital organs and systems are laid in the fetus. There is no data on how the drug can affect early fetal development. And in general, the instructions for use say that the effect on the body has not been studied, you can drink it only if the benefit for the woman outweighs the risk for the baby.

Features of taking sedative "Persen Forte"

Doctors recommend that expectant mothers take a sedative before bed. According to experts, during pregnancy, night reception "Persen" will eliminate anxiety, anxiety, and provide a healthy sleep. Some people will have a very reasonable question: "Why use it just before bedtime?"

The fact is that extracts of herbs such as lemon balm and valerian, which are part of the drug, can slightly slow down the reaction, they have a sedative effect.

Therefore, if you are going to spend the whole day on your feet away from home, then it is better to refrain from sedatives. If you plan to sit at home, relax, or arrange an evening walk, but in the company of your beloved spouse or relatives, then you can take the remedy during the day, but no more than 1-2 capsules.

Another point that I would like to remind all pregnant women: never take medications without consulting a doctor, as it may be unsafe for your health and fetal development. The most correct solution is to consult a doctor to whom you must tell about your problems. And the specialist, in turn, will select the required dosage of "Persen" or recommend another medication.

About side effects and contraindications

If you believe the instructions for this sedative, then it has practically no contraindications.

True, there are some exceptions when it is better not to use "Persen":

• In the presence of individual intolerance to the components that make up the drug;
• With a tendency to lower blood pressure. In this case, the drug should be taken with caution. True, such patients often have to completely abandon Persen for health reasons and switch to another drug.

It is worth noting the fact that this sedative, when taken simultaneously with some anesthetic drugs, as well as drugs to lower blood pressure, can enhance the effect of the latter.

Therefore, in such cases, extra caution does not hurt.

Of the side effects, we can note the manifestations of allergies, weakness, and with prolonged use of the medicine, problems with stool (constipation).

In case of an overdose, the patient may experience dizziness, drowsiness, unpleasant cramps in the stomach, tremors of the limbs. With the listed symptoms, you should immediately call a doctor.

Instructions for use

The period of carrying a baby in the womb does not always do without exciting moments for the expectant mother, because during this period any responsible woman will worry about the results of important screenings, the successful course of pregnancy, and the intrauterine state of the fetus. Many pregnant women worry about the fear of the upcoming birth. Almost all experts agree that excessive stresses of the expectant mother can adversely affect the condition of the fetus in the womb, primarily due to hypoxia, which occurs when there is insufficient supply of oxygen and nutrients to the fetus. If emotional stress cannot be avoided, a pregnant woman needs outdoor walks, rest, positive thoughts and emotions. In the event that these measures do not give the necessary sedative effect, the obstetrician-gynecologist who supervises the pregnancy may recommend the use of herbal sedatives. When choosing alternative medicines, experts prefer Persen. The use of sedatives and often prescribed drugs based on phenobarbital is strictly prohibited during pregnancy.

• Sedatives during pregnancy
• Insomnia during pregnancy
• Medicines during pregnancy

Can Persen during pregnancy?

This drug has a strictly plant origin, as it contains extracts of sedative herbs such as valerian, motherwort, lemon balm and peppermint. Persen does not contain phenobarbital, which has a teratogenic effect and negatively affects the formation of the central nervous system of the fetus. This drug is approved during pregnancy and is used in complex therapy and prevention of threatened miscarriage. Doctors often prescribe Persen to eliminate stress, improve sleep, and normalize the nervous system of a pregnant woman. The use of the drug in doses not exceeding therapeutic doses does not have an embryotoxic and teratogenic effect on the developing fetus.

Indications for use

Obstetricians-gynecologists during pregnancy try not to resort to the appointment of sedatives, even those allowed during the period of gestation. Taking the drug is allowed in the first trimester, but it is important for a pregnant woman to avoid taking any medications at the time of laying the vital organs of the fetus. In the case when it is impossible to do without sedatives, the harm from the stress of the mother itself to the fetus will be much greater than the likelihood of harm from the taken herbal sedative pill. The main indications for Persen's appointment are neuratenic states, insomnia, anxiety, tearfulness and irritability, uterine hypertonicity (as a mild antispasmodic). After the 12th week of pregnancy, the drug can be used after consulting a doctor.

How to take Persen

During pregnancy, the regimen for taking the drug is selected by a specialist individually and ranges from 1 to 2 tablets per dose, three times a day for 14-21 days. The tablets must be taken orally with plenty of liquid. It is not recommended to prescribe sedatives even of herbal origin independently, without consulting a gynecologist.

Should I take Persen® during pregnancy?

When carrying a child, women often become anxious, suspicious, nervous. They often get upset for various reasons and even without them. Hormonal changes are not in vain for the nervous system. In addition, toxicosis also does not affect the best way... Finally, many are afraid of childbirth and pain.

However, nervousness is not good for the child. Stressful expectant mothers need help. But chemical tranquilizers and antidepressants at this time are strictly prohibited. They have a systemic effect on the body, quite strongly affect the metabolism.

In such a situation, doctors can recommend the drug "Persen-Forte" as one of the safest medicines. True, it should not be used in the first trimester, since it is at this time that the main organs of the child are formed.

The use of Persen® during pregnancy on different

Is it possible to drink Persen during pregnancy at different stages of pregnancy can be presented for clarity in the form of a table. And at the same time, it is worth considering the individual characteristics of the body of each woman.

What individual characteristics are we talking about? Here, in particular, we mean the personal reaction of the body. In addition, the doctor always weighs the pros and cons when prescribing. If a woman has very rapid toxicosis, frequent tantrums, tears, she cannot fall asleep, then Persen® can be advised for her in the first trimester as an exception.

Dosage form and composition

Persen® is available in two dosage forms. This is "Persen", tablets containing 0.025 peppermint extract, the same amount of lemon balm and 0.05 valerian extract. And "Persen-Forte" in capsule form. Here the composition is the same, but different proportions, higher concentration.

- Mint during pregnancy - indications and contraindications

- Valerian during pregnancy

What effect

The drug relieves irritability, anxiety, removes spasms. Sometimes it cheers up. The effect is especially noticeable with excessive overexcitation. In the normal state, it does not cause drowsiness, but with chronic fatigue, overload, hormonal changes, such an effect can still appear. Therefore, doctors recommend that pregnant women drink at night or before they decide to sleep.

When is it indicated for use?

The medicine is prescribed for neuroses that do not need to be treated with potent drugs. Such diseases are accompanied by increased irritability, insomnia, background constant or frequent anxiety, and decreased attention.

Also, Persen® can be prescribed for the abolition of potent sedative medications in order to mitigate the negative effects. It helps quite well with VSD. It is also prescribed as a preventive measure for severe stress. And for pregnant women - to help the body suffering from hormonal shocks, with severe toxicosis that affects the nervous system.

How to apply?

The recommended dose is 2-3 Persen® tablets or 1-2 capsules 2 to 3 times a day. Pregnant women can be recommended 1 time at night if negative symptoms are not too pronounced. But in general, the dosage for expectant mothers is always selected individually, depending on the situation. For insomnia, you need to use it 1 hour before bedtime. It is better to drink water, in cold weather - warm. If you have trouble sleeping, tea is undesirable, as it contains caffeine, which can have the opposite effect. The total duration of the course is determined by the doctor.

Side effects and contraindications

With regard to side effects, the instructions say almost nothing, except for the possibility of constipation with prolonged use. But this is an important warning for pregnant women! When carrying a child, hormonal changes and pressure on the intestines lead to stagnation of feces, problems with defecation. Therefore, you should not abuse everything that can aggravate this.

Only individual intolerance is indicated as contraindications. This is due to the herbal components of the drug. There are no synthetic substances even in the form of additional ingredients. Drink with caution when low blood pressureas the medication can make this condition worse.

Interaction with other drugs

Doctors advise always to be very careful when taking several medications at once. Especially during pregnancy. So, Persen® enhances the effect of most sleeping pills, so you should not take it simultaneously with them! Similarly, it acts in relation to antihypertensive and analgesic drugs.

Overdose

In case of an overdose, the medicine can cause hand tremors, weakness, nausea, dizziness, pain in the internal organs of a spastic nature. True, for this in a relatively short period of time, you need to drink 60 tablets or 25 capsules. So overdose is unlikely.

Analogs

Sometimes it happens that the remedy is ineffective. Or it is difficult for some reason to get it in a particular region. In short, there is a need for effective analogues. Various herbal preparations are suitable for pregnant women. The main thing is without alcohol! So, it can be valerian extract (the effect is weaker, but still there), motherwort in tablets, Novo-passit, Alora (peony extract). There are also combined formulations, for example, Dormiplant, Menovalen, Sedasen. In general, there are quite a lot of herbal preparations, so in the absence of one option, you can always pick up some other.

The medicine doesn't help

Sometimes it happens that Persen® does not cope with the task at hand. Pregnant women complain that the problem of insomnia does not go away, as well as nervousness, irritability and other unpleasant symptoms. According to doctors, there may be various reasons for this:

• The remedy did not have time to work. Most herbal medicines are cumulative. In addition, they generally strengthen the nervous system, restore it, but this effect takes time. The first result for some comes immediately, for some - after a couple of days, and for some pregnant women - after a week or even more. Recall that the duration of the course is always set by the doctor.
• High expectations. Persen® could act, but weaker or slower, and sometimes both, than the patient would like. This in itself can upset, cause an aggravation of the condition. Therefore, while taking the medicine, try to relax on your own, rest. Meditations, at least short walks in the fresh air, airing the room, and massaging your feet or other parts of the body, if possible, help. Sometimes warm milk or other drinks, to which the body reacts in a neutral-positive way, soothes well. Of course, in this case it will not be possible to say unequivocally what exactly worked - the medicine or the described actions in the complex. But for a pregnant woman, her well-being should be more important than the desire to prove that the drug is not effective to the detriment of her own health and the condition of the child.
• Irregularity of reception. Persen®, like many other medicines, helps with long-term systematic use. Breaking the cycle can lead to a weakening of the effect.
• Insufficient dosage. Doctors may first prescribe 1 capsule 1 time per day in the evening. But periodically, the amount of medicine still needs to be increased.
• Further deterioration of the condition. Sometimes it happens that when taking Persen® there is an effect. It's just that in reality, the patient's well-being worsened by different reasons, ranging from additional stress and ending with hormonal imbalances. And since the drug worked, then subjectively in the end it seems that everything remained the same, the drug did not give anything. Although without the use of the remedy, the condition could have become even worse.
• Use of other medicines. The interaction of Persen® with far from all compounds has been studied in detail. Therefore, the effects can sometimes be unexpected. That's why you shouldn't self-medicate.
• Lack of efficiency. Unfortunately, some pregnant women require strong enough tranquilizers and antidepressants. Persen® is not able to handle really serious cases. He can soften the condition in such situations, but even then not always. The decision on the provision of medical care, its nature and scope is made by the doctor.

As you can see, there are many reasons, they are all different. Sometimes you can observe a unique combination of several at once. In any case, if an allergy occurs to Persen®, or if the medicine does not have the desired effect for a long time, the doctor cancels it.

Sources

• https://mjusli.ru/ja_mama/planirovanie-beremennosti/persen-pri-beremennosti
• http://nedeli-beremennosti.com/persen-pri-beremennosti/
• http://www.babysu.ru/trimestry-beremennosti/persen-pri-beremennosti-3-trimestr.html

13.01.2017

Review about possible harm herbal ingredients in Persen, if this medicine will be taken by a woman in a position, violating the restrictions in the instructions.

In one of the comments, a Facebook user expressed disagreement about the information in the publication, which talks about the mistaken use of drugs contraindicated in pregnant women. In particular, user : “Why not Persen? Mint with motherwort ... Pregnant women get sick, often depressed, sleep poorly, can they do anything? "

The official instructions for drugs Persen (Instruction No. P N016317 / 01 as amended on 01/28/2016) and Persen Night (Instruction No. P N0113803 / 01 as amended on 11/20/15) indicate that drugs are prohibited for use throughout pregnancy.

We do not have data on the relevant modules of the registration dossier of Persen, so we can only assume what caused the restrictions on its use in pregnant women. Firstly, Persen contains extracts of mint, lemon balm and valerian rhizomes. Secondly, there has been no high quality research on these components to date. There are several reasons for this: first of all, ethical issues regarding pregnant women, as well as the required sample size. So, in order to detect a statistically significant increase in the number of spontaneous abortions from 6% to 7% in the study group, it is necessary to study the course of pregnancy in more than 19,000 women taking this drug 1. Therefore, data on the safety of using a particular herbal preparation in pregnant women were obtained on the basis of a few clinical studies of low quality, data from individual clinical observations, pharmacological experiments, and spontaneous reports of adverse drug reactions 1.

We have not found any evidence of peppermint negative effects on the fetus or pregnancy, on the contrary, according to research by some authors, peppermint is one of the plants most commonly used by expectant mothers 2. This is due to a positive effect on the incidence and severity of nausea and vomiting, as well as the likely inhibitory effect on the production of acid in the stomach. These effects have not been confirmed in the works of other authors, so the question of the effectiveness of using mint essential oil in pregnant women remains open 3. The undesirability of using mint without proper medical supervision by pregnant women is stated in the WHO monograph (Monographs on Selected Medicinal Plants) 4.

With regard to another plant - mint mint (Méntha), there is enough clinical and experimental evidence of its negative effect on the tone of the myometrium and the abortive effect 5.

No convincing data have been obtained about the rationality of using the second component of the Persen combination - lemon balm. The use of this plant as a hypnotic agent is quite common, but data on the possibility of developing withdrawal and addiction syndrome should not be ignored 6. The lack of data on the safety of lemon balm use by pregnant women is highlighted in many sources, including in a special WHO monograph 4. It was she who served as the reason for the recommendation to limit its use in pregnant women.

The opinions of different researchers about the advisability of using valerian by pregnant women basically coincide: they are negative. As stated, the number of studies of acceptable quality conducted on this drug is extremely small to consider it safe. Several experimental studies have shown that valerian reduces the amount of zinc in the brain 7. In addition, the results of experimental studies were published, which demonstrated the cytotoxic, mutagenic and carcinogenic effects of valepotriates contained in the extract of valerian rhizomes 8, 9, 10, 11, 12. Although in vitro effects have not been confirmed in in vivo studies, concerns about the safety of using valerian in pregnant women remain. Recommendations to limit the use of this component of the drug are formulated in the WHO monograph 4, the recommendations of the European Scientific Society of Phytotherapists 13, the review for health professionals published by the US National Institutes of Health 14, and other sources.

As for the motherwort herb mentioned in the user's comment, it is not included in the Persen medicine. This plant is not recommended by some pharmaceutical companies for use during pregnancy. This is due to the published data on the effect of motherwort components, in particular leonurin, on the tone of the myometrium, which can lead to abortion 15. It should be noted that this effect was noted in experimental studies. Recommendations for limiting motherwort use in pregnant women can be found in many sources 16, 17, as well as in the British Botanical Compendium.

The instruction for the use of a medicinal product is approved by order of the Ministry of Health and is an official document regulating the use of a medicinal product. Official instructions are the only source of information for the Medicines and Pregnancy mobile application, which eliminates mistakes in prescribing medicines for women in a position.

Any deviation from the requirements of the instructions is a violation of the requirements of the order of the Ministry of Health and, in case of complications of therapy, can be used against the prescribing specialist. The recommendation for the use of any drug should be based on a careful assessment of the possible benefits of its use and the potential risk of complications.

Sources:

1. Low Dog T. The use of botanicals during pregnancy and lactation. Altern Ther Health Med. 2009 Jan-Feb; 15 (1): 54-8.
2. Moussally K et al. Exposure to specific herbal products during pregnancy and the risk of low birth weight. Altern Ther Health Med. 2012 Mar-Apr; 18 (2): 36-43.
3. Pasha H et al. Study of the effect of mint oil on nausea and vomiting during pregnancy. Iran Red Crescent Med J. 2012 Nov; 14 (11): 727-30.
4. Monographs on Selected Medicinal Plants - Volume 2, http://apps.who.int/medicinedocs/pdf/s4927e/s4927e.pdf
5. Soares PM et al. Inhibitory effects of the essential oil of Mentha pulegium on the isolated rat myometrium. Planta Med. 2005 Mar; 71 (3): 214-8.
6. Demirci K et al. Does Melissa Officinalis Cause Withdrawal or Dependence? Med Arch. 2015 Feb; 69 (1): 60-61.
7. Mahmoudian A et al. Effects of valerian consumption during pregnancy on cortical volume and the levels of zinc and copper in the brain tissue of mouse fetus. Zhong Xi Yi Jie He Xue Bao. 2012 Apr; 10 (4): 424-9.
8. Bounthanh C, Richert L, Beck JP, Haag-Berrurier M, Anton R. The action of valepotriates on the synthesis of DNA and proteins of cultured hepatoma cells [J]. Planta Med 1983, 49 (11): 138-142.
9. Bos R, Hendriks H, Scheffer JJC, Woerdenbag HJ. Cytotoxic potential of valerian constituents and valerian tinctures [J]. Phytomedicine 1998, 5 (3): 219-225.
10. Tortarolo M, Braun R, Hübner GE, Maurer HR. In vitro effects of epoxide-bearing valepotriates on mouse early hematopoietic progenitor cells and human T-lymphocytes [J]. Arch Toxicol 1982,51 (1): 37-42.
11. Von der Hude W, Scheutwinkel-Reich M, Braun R. Bacterial mutagenicity of the tranquilizing constituents of Valerianaceae roots [J]. Mutat Res, 1986,169 (1-2): 23-27.
12. Bounthanh C, Bergmann C, Beck JP, Haag-Berrurier M, Anton R. Valepotriates, a new class of cytotoxic and antitumor agents [J]. Planta Med, 1981, 41 (1): 21-28.
13. European Scientific Cooperative on Phytotherapy: Valerianae radix: valerian root. In: Monographs on the Medicinal Uses of Plant Drugs. Exeter, UK: ESCOP, 1997: 1-10.
14. Overview for Healthcare Professionals published by the US National Institutes of Health https://ods.od.nih.gov/factsheets/Valerian-HealthProfessional/
15. De Boer HJ, Cotingting C. Medicinal plants for women’s healthcare in southeast Asia: a meta-analysis of their traditional use, chemical constituents, and pharmacology. J Ethnopharmacol. 2014 Feb 3; 151 (2): 747-67.
16. Herbal Medicine in Depression (edited by Clara Grosso, Springer International Publishing Switzerland, 2016.
17. Mills S., Bone K. The Essential Guide to Herbal Safety. Churchill Livingstone, 2004.

Ph.D. A.V. Matveev